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. 2017 Sep 5;6:12. Originally published 2017 Jan 5. [Version 2] doi: 10.12688/f1000research.10493.2

Figure 4. Study design and organization of the ISA-Tab instances for the C57BL6-pMRTP-SW study.

Figure 4.

A. Switching study concept and study design and setup. B. ISA-Tab splitting strategy of endpoints. The data production (DP) and processing (PR) instances describe the experimental setup and processing steps, from raw to processed data. Transcriptomics processing is separated by tissue, resulting in individual PR ISA-Tab instances. C. A more complicated lipidomics scheme was necessary because the experiment was performed independently for different groups of lipids, and hence separate DP instances were used for each mass spectrometry platform/set of methods. Processing was then performed per tissue, resulting in separate PR instances for blood, right lung, and liver. For simplicity, data files are not depicted here.