Table 2.
Twenty-four-hour ambulatory multichannel pH-impedance measurement results and BEWE scores at baseline and at follow-up off-PPI in patients with progression or no progression of dental erosion after a median of 1 year treatment with esomeprazole 20 mg twice-daily. Means and 95% confidence intervals are shown
| At baseline | At follow-up | |||
|---|---|---|---|---|
| All patients N = 72 | All patients N = 72 | No erosion progression N = 53 | Erosion progression N = 19 | |
| % time with pH < 4a | 16.5 (12.6–20.4) | 11.7 (5.7–17.7) | 10.2 (6.7–13.7) | 16.9 (6.4–27.4) |
| % time with pH < 5.5a | 43.5 (33.3–53.7) | 40.2 (31.1–49.3) | 40.5 (26.6–54.4) | 37.7 (26.6–48.8) |
| DeMeester scorea | 56.4 (43.2–69.6) | 46.3 (34.3–54.3) | 41.7 (31.8–51.6) | 69.1 (40.1–98.1) |
| Number of all reflux episodes (pH < 7)b | 85 (64–106) | 52 (41–63)* | 53 (46–61)** | 52 (33–71) |
| Number of acidic reflux episodes (pH < 4)b | 54 (41–67) | 41 (31–50) | 43 (37–49) | 33 (24–42) |
| Number of weakly acidic reflux episodes (pH > 4–pH < 7)b | 31 (24–38) | 12 (8–18)** | 10 (8–12)** | 19 (10–28) |
| % proximal reflux (15 cm above lower oesophageal sphincter)a | 26 (20–32) | 23 (17–29) | 23 (19–27) | 21 (15–27) |
| BEWE scoresb | 12 (11–16) | 13 (12–15) | 12 (11–13) | 14 (13–16)*** |
BEWE Basic erosive wear examination (9–13 medium, >13 extensive erosive disease) [7]
ameans (95% confidence intervals)
bmedian (interquartile range)
*p < 0.05 versus baseline **p < 0.01 versus baseline ***p < 0.01 group with erosion progression vs group without erosion progression