Table 3.
Significant associated genes identified by RareProb-C comparing to the ones highlighted in the integrated germline-somatic research on the same dataset
| Gene name | RareProb-C | OV research |
|---|---|---|
| BRCA1 | 3.0×10−14 | 2.0×10−8 |
| BRCA2 | 4.5×10−15 | 8.9×10−6 |
| CHEK2 | 2.4×10−15 | 0.11∗ |
| BRIP1 | 5.2×10−10 | 0.11∗ |
| USP6 | 3.3×10−12 | Not Significant ∗ |
| PALB2 | 5.2×10−10 | Not Significant ∗ |
| ATM | 2.9×10−9 | Not Significant |
| PCSK7 | 7.6×10−8 | Not Significant |
| FLT3 | 5.8×10−7 | Not Significant |
*These 4 genes are considered to contribute to ovarian cancer susceptibility in the research, although without reaching the significance threshold (P<0.05)