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. 2017 Oct 25;48:67. doi: 10.1186/s13567-017-0471-0

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Polymerase activities of reconstituted RNP complex and correlation of virulence of recombinant virus with polymerase activity. Comparison of polymerase activities of different ribonucleoprotein complexes with A indicated a single polymerase gene or NP from the CZ or JY virus, and with B indicated two or three polymerase genes from the CZ or JY virus, and with C indicated single or double substitution in the PB2 of the CZ or JY virus. Values represent the mean ± SD of the results of three independent experiments and are standardized to those of the JY (100%). The relative polymerase activity value of each recombinant virus was compared with that of the corresponding parental virus (*P < 0.05; **P < 0.01). D Correlation of virulence of recombinant virus with polymerase activity. The MLD₅₀ of viruses were plotted (inverted axis) against their polymerase activities.