Table 1.
Distribution of CZ and JY viruses and their recombinant viruses in mouse organs at 3 and 5 dpi
| Virus | Virus titer (log10EID50/1 mL ± SD) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Heart | Liver | Spleen | Lung | Kidney | Brain | |||||||
| 3 dpi | 5 dpi | 3 dpi | 5 dpi | 3 dpi | 5 dpi | 3 dpi | 5 dpi | 3 dpi | 5 dpi | 3 dpi | 5 dpi | |
| wt-CZ | 2.13 ± 0.53 | 3.63 ± 0.18 | 1.63 ± 0.18 | 3.25 ± 0.15 | 4.00 ± 0.00 | 5.63 ± 0.53 | 5.75 ± 0.00 | 2.25 ± 0.00 | 3.13 ± 0.18 | 2.25 ± 0.71 | 5.38 ± 0.18 | |
| r-CZ | 1.75 ± 0.00 | 3.25 ± 0.00 | – | 3.13 ± 0.53 | 3.00 ± 0.35 | 1.50 ± 0.35 | 5.63 ± 0.18 | 5.63 ± 0.18 | 1.38 ± 0.18 | 3.63 ± 0.18 | 2.25 ± 0 | 5.63 ± 0.18 |
| CZ-JYPB2 | – | 1.75 ± 0.71 | – | – | 2.00 ± 0.35 | 1.63 ± 0.18 | 3.88 ± 0.88 | 5.25 ± 0.71 | – | 1.88 ± 0.88 | – | 1.75 ± 0.71 |
| CZ-JYPB1 | 1.50 ± 0.35 | 1.88 ± 0.88 | – | – | 2.25 ± 0.71 | 2.00 ± 0.35 | 4.00 ± 1.06 | 5.13 ± 0.53 | 1.75 ± 0.00 | 1.25 ± 0.00 | 1.50 ± 0.35 | 2.75 ± 0.00 |
| CZ-JYPA | 1.25 ± 0.00 | 2.00 ± 0.35 | – | – | 1.38 ± 0.18 | 1.50 ± 0.35 | 5.00 ± 0.35 | 5.00 ± 0.35 | 1.38 ± 0.18 | 1.25 ± 0.00 | – | 1.38 ± 0.18 |
| CZ-JYHA | 1.38 ± 0.18 | 2.63 ± 0.18 | – | – | 3.00 ± 0.35 | – | 4.88 ± 0.53 | 5.38 ± 0.53 | 2.13 ± 0.53 | 1.50 ± 0.35 | 1.50 ± 0.35 | 3.50 ± 0.00 |
| CZ-JYNP | 1.25 ± 0.00 | 3.13 ± 0.53 | – | – | 1.50 ± 0.35 | – | 4.63 ± 0.53 | 5.50 ± 0.35 | 1.38 ± 0.18 | 2.38 ± 0.18 | 1.5 ± 0.35 | 4.38 ± 0.18 |
| CZ-JYNA | 2.63 ± 0.18 | 3.38 ± 0.18 | – | 1.75 ± 0.71 | 3.25 ± 0.00 | 2.13 ± 1.24 | 5.00 ± 0.35 | 4.75 ± 0.35 | 3.25 ± 0.00 | 2.00 ± 0.35 | 1.88 ± 0.53 | 3.50 ± 0.00 |
| CZ-JYM | 3.50 ± 0.00 | 3.25 ± 1.41 | – | 1.88 ± 0.88 | 3.50 ± 0.35 | 2.63 ± 0.18 | 5.38 ± 0.18 | 5.75 ± 0.00 | 1.88 ± 0.53 | 3.00 ± 0.71 | 2.63 ± 0.18 | 4.00 ± 1.06 |
| CZ-JYNS | 1.88 ± 0.53 | 3.00 ± 0.71 | – | – | 2.25 ± 0.71 | – | 5.25 ± 0.00 | 4.13 ± 0.53 | 2.25 ± 0.00 | 2.00 ± 0.35 | – | 3.00 ± 0.71 |
| wt-JY | – | 2.93 ± 0.50 | – | – | – | – | 2.63 ± 0.18 | 3.63 ± 0.18 | – | – | – | – |
| r-JY | – | – | – | – | – | – | 3.75 ± 0.00 | 3.13 ± 0.88 | – | – | – | – |
| JY-CZPB2 | – | 3.13 ± 0.53 | – | – | 2.63 ± 0.18 | 1.50 ± 0.35 | 5.50 ± 0.00 | 4.88 ± 0.53 | 1.63 ± 0.18 | 2.00 ± 0.35 | – | – |
| JY-CZPB1 | – | – | – | – | – | – | 2.88 ± 0.88 | 3.63 ± 0.18 | – | – | – | – |
| JY-CZPA | – | – | – | – | – | – | 3.00 ± 0.71 | 3.63 ± 0.18 | – | – | – | – |
| JY-CZHA | – | – | – | – | – | – | 4.00 ± 0.35 | 3.00 ± 0.35 | – | – | – | – |
| JY-CZNP | – | – | – | – | – | – | 4.50 ± 0.00 | 3.75 ± 0.35 | – | – | – | – |
| JY-CZNA | – | – | – | – | – | – | 3.13 ± 0.53 | 2.63 ± 0.18 | – | – | – | – |
| JY-CZM | – | – | – | – | – | – | 4.38 ± 0.18 | 3.50 ± 0.00 | – | – | – | – |
| JY-CZNS | – | – | – | – | – | – | 4.25 ± 0.71 | 3.88 ± 0.53 | – | – | – | – |