Figure 5.
Effect of lipid content of liposome association. A) Liposomes with specific cholesterol/phospholipid content simulating the lipid content of either exosomes or cells were incubated with PC3 cells. Association of 15/85 Cell Liposomes is significantly lower than 30/70 Exosome Liposomes (p<.05). B) Liposomes prepared from the lipid extracts of PC3-derived exosomes and PC3 cells were incubated with PC3 cells. Association of the liposomes composed of exosome lipids are significantly greater (p<.05). C) Association of liposomes mimicking the commercial product DaunoXome (PC:Cholesterol 2:1 mole ratio) was compared to liposomes prepared from exosome lipid extracts. Association of liposomes prepared from exosome lipids was significantly higher (p<.05).