Table I. Cytokine and Chemokine Response to Lipoplex Formulations.

Cytokine and chemokine levels were measured in blood from mice repeatedly administered different lipoplex formulations as described in the methods. Levels that were significantly higher than that in mice administered PBS (t-test, p > 0.05) are indicated with an asterisk.

	Sphingosinebased	CpG – rich Plasmid	PEG-DSPE	DOTAP	Lipofectamine
BLC			*	*	*
C5			*	*	*
G-CSF			*	*	*
GM-CSF			*		*
I-309			*		*
Eotaxin			*	*	*
sICAM-1					*
IFN-gamma			*		*
IL-1alpha		*	*		*
IL-1beta			*	*	*
IL-1ra			*		*
IL-2			*		*
IL-3			*		*
IL-4					*
IL-5			*	*	*
IL-6			*		*
IL-7		*	*	*	*
IL-10			*		*
IL-13		*	*		*
IL-12p70					*
IL-16			*		*
IL-17			*		*
IL-23			*	*	*
IL-27			*	*	*
IP-10			*	*	*
I-TAC					*
KC	*	*	*		*
M-CSF			*	*	*
JE			*		*
MCP-5			*		*
MIG			*		*
MIP-1alpha			*		*
MIP-1beta			*		*
MIP-2			*		*
RANTES					*
SDF-1					*
TNF-alpha				*	*