Table 2.
Genotype distribution and allele frequencies for IL 1β gene cluster SNPs (rs1143629, rs1143634, and rs1143643) and IL-1RA gene cluster SNPs (rs315951, rs315952, and rs1794065) in patients with high and low levels of EARR
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|---|---|---|---|---|---|---|
| Group | Genotype, n | Allele, n | ||||
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| AA | AG | GG | A | G | ||
| IL-1β rs1143629 (p=0.460) | High EARR (n=5) | 1 (20.0%) | 3 (60.0%) | 1 (20.0%) | 5 (50.0%) | 5 (50.0%) |
| Low EARR (n=12) | 4 (33.3%) | 7 (58.3%) | 1 (8.3%) | 15 (62.5%) | 9 (37.5%) | |
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| GG | GA | AA | G | A | ||
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| IL-1β rs1143634 (p=0.031) | High EARR (n=5) | 5 (100.0%) | 0 (0.0%) | 0 (0.0%) | 10 (100.0%) | 0 (0.0%) |
| Low EARR (n=12) | 5 (41.7%) | 7 (58.3%) | 0 (0.0%) | 17 (70.8%) | 7 (29.2%) | |
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| CC | CT | TT | C | T | ||
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| IL-1β rs1143643 (p=0.503) | High EARR (n=5) | 3 (60.0%) | 2 (40.0%) | 0 (0.0%) | 8 (80.0%) | 2 (20.0%) |
| Low EARR (n=12) | 5 (41.7%) | 7 (58.3%) | 0 (0.0%) | 17 (70.8%) | 7 (29.2%) | |
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| CC | CG | GG | C | G | ||
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| IL-1RA rs315951 (p=0.160) | High EARR (n=5) | 2 (40.0%) | 2 (40.0%) | 1 (20.0%) | 6 (60.0%) | 4 (40.0%) |
| Low resorption (n=12) | 8 (66.7%) | 4 (33.3%) | 0 (0.0%) | 20 (83.3%) | 4 (16.7%) | |
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| TT | TC | CC | T | C | ||
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| IL-1RA rs315952 (p=0.160) | High EARR (n=5) | 2 (40.0%) | 2 (40.0%) | 1 (20.0%) | 6 (60.0%) | 4 (40.0%) |
| Low EARR (n=12) | 8 (66.7%) | 4 (33.3%) | 0 (0.0%) | 20 (83.3%) | 4 (16.7%) | |
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| AA | AG | GG | A | G | ||
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| IL-1RA rs1794065 (p=0.631) | High EARR (n=5) | 1 (20.0%) | 1 (20.0%) | 3 (60.0%) | 3 (30.0%) | 7 (70.0%) |
| Low EARR (n=12) | 1 (8.3%) | 3 (12.5%) | 8 (66.7%) | 5 (20.8%) | 19 (79.2%) | |