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MK-8242 in vivo objective response activity for ALL models. ALL-2 (B-precursor), ALL-4 (B-precursor; BCR-ABL), ALL-8 (T-cell ALL) and MLL-7 (Infant, Precursor B-ALL). A. Kaplan-Meier curves showing the EFS, B. median leukemia engraftment as detected in peripheral blood, and C. individual leukemia engraftment (right). Controls (gray lines); Treated (black lines), statistical significance (p values) of the difference between treated and control groups are included.
