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. Author manuscript; available in PMC: 2018 Sep 11.
Published in final edited form as: Curr Biol. 2017 Aug 24;27(17):2684–2691.e7. doi: 10.1016/j.cub.2017.07.051

Figure 3. Modulation of Patient AE’s intraoperative behavioral performance as a function of direct electrical stimulation strength.

Figure 3

To evaluate whether the likelihood of an error was related to stimulation strength, we sought to better characterize the electrical stimulation parameters that generated major and minor errors. This analysis is possible because the surgeons vary the current amplitude throughout the mapping session to ensure that stimulation is being delivered at just below the afterdischarge threshold. Stimulation sites are recast as spheres and color-coded with respect to stimulation strength (mA). A. Stimulation sites associated with major errors in melody repetition were associated with electrical stimulation that ranged from 3.5 to 4.5 mA, indicating that Patient AE’s major errors do not derive solely from stimulations with the strongest current that was delivered. B. Stimulation sites associated with minor errors in melody repetition were present for the full range stimulation strength that was used. C. Stimulation sites associated with correct melody repetition were present for the full range stimulation strength that was used. D. Sentence repetition and picture naming performance contained both 3.5 and 4.5 mA stimulation events.