Table 1.
Associations between genetic ancestry and demographic and clinical characteristics of Latinas in the Kaiser Permanente Northern California Pathways Study (n=506).
| N (%) | Indigenous Ancestry | European Ancestry | |||
|---|---|---|---|---|---|
| Median (IQR) | P* | Median (IQR) | P* | ||
| Age at Diagnosis | |||||
| <40 Years | 40 (7.9) | 39.8 (23.9) | <0.0001 | 51.4 (22.1) | 0.0002 |
| 40–50 Years | 138 (27.3) | 38.2 (23.9) | 52.9 (23.4) | ||
| 50–60 Years | 157 (31.0) | 31.2 (25.6) | 57.1 (25.3) | ||
| ≥60 Years | 171 (33.8) | 28.9 (30.1) | 59.1 (32.4) | ||
| Body Mass Index | |||||
| <25 kg/m2 | 136 (27.8) | 30.1 (27.4) | 0.02 | 59.7 (30.4) | 0.01 |
| 25–29.9 kg/m2 | 157 (32.0) | 36.2 (22.1) | 52.6 (23.3) | ||
| 30–34.9 kg/m2 | 105 (21.4) | 32.5 (20.1) | 55.8 (23.1) | ||
| ≥35 kg/m2 | 92 (18.8) | 34.4 (30.4) | 57.3 (25.0) | ||
| Education Level | |||||
| High School | 171 (33.9) | 38.4 (22.1) | <0.0001 | 51.3 (22.4) | <0.0001 |
| Some College | 200 (39.6) | 31.3 (24.8) | 57.7 (22.2) | ||
| College Graduate | 77 (15.3) | 31.1 (26.0) | 56.9 (29.4) | ||
| Post-Graduate Degree | 57 (11.3) | 13.8 (30.2) | 77.9 (28.7) | ||
| Household Income | |||||
| <$25,000 | 60 (11.9) | 37.5 (20.5) | <0.0001 | 53.4 (24.6) | <0.0001 |
| $25000–49,999 | 104 (20.6) | 33.5 (25.0) | 56.5 (22.6) | ||
| $50,000–89,999 | 165 (32.6) | 30.0 (28.1) | 59.0 (28.7) | ||
| >$90,000 | 92 (18.2) | 28.0 (31.2) | 62.8 (34.3) | ||
| Not disclosed | 85 (16.8) | 38.3 (20.4) | 50.2 (20.9) | ||
| AJCC Stage | |||||
| Stage I or II | 433 (86.3) | 32.3 (25.3) | 0.45 | 56.9 (24.9) | 0.56 |
| Stage III or IV | 69 (13.7) | 35.2 (26.1) | 56.1 (24.8) | ||
| Estrogen Receptor (ER) Positive | |||||
| No | 94 (18.7) | 31.0 (22.9) | 0.13 | 59.2 (24.0) | 0.21 |
| Yes | 408 (81.3) | 33.0 (27.0) | 56.4 (25.8) | ||
| HER-2 Positive | |||||
| No | 404 (84.3) | 32.4 (26.5) | 0.72 | 56.2 (25.7) | 0.56 |
| Yes | 75 (15.7) | 31.7 (26.5) | 59.0 (22.9) | ||
| Triple-Negative | |||||
| No | 439 (86.8) | 32.6 (26.5) | 0.16 | 56.6 (25.6) | 0.35 |
| Yes | 67 (13.2) | 33.3 (32.2) | 57.6 (26.7) | ||
| Chemotherapy | |||||
| No | 229 (45.9) | 32.2 (24.6) | 0.53 | 56.3 (25.3) | 0.73 |
| Yes | 270 (54.1) | 33.2 (26.8) | 57.5 (25.2) | ||
| Hormonal Therapy | |||||
| No | 138 (27.4) | 31.7 (23.5) | 0.35 | 57.6 (24.2) | 0.46 |
| Yes | 366 (72.6) | 33.0 (27.0) | 56.4 (26.0) | ||
| Radiotherapy | |||||
| No | 283 (56.4) | 33.1 (27.3) | 0.30 | 56.7 (25.4) | 0.36 |
| Yes | 219 (43.6) | 32.3 (24.8) | 57.0 (25.9) | ||
| Surgery | |||||
| No Surgery | 5 (1.0) | 25.8 (32.3) | 0.72 | 55.6 (34.6) | 0.70 |
| Lumpectomy | 291 (58.0) | 33.1 (25.7) | 57.0 (26.4) | ||
| Simple or Radical Mastectomy | 206 (41.0) | 31.7 (26.4) | 56.7 (24.0) | ||
*
p-values obtained by fitting univariable regression models for type of ancestry on each characteristic;
IQR, Interquartile Range