Table 2.

Hazards ratios for the effect of Indigenous American ancestry on primary and secondary outcomes.

	Breast Cancer Recurrence		Breast Cancer-Specific Mortality		All-Cause Mortality		Disease Free Survival
	Crude HR (95% CI)	Adjusted HR¥ (95% CI)	Crude HR (95% CI)	Adjusted HR¥ (95% CI)	Crude HR (95% CI)	Adjusted HR¥ (95% CI)	Crude HR (95% CI)	Adjusted HR¥ (95% CI)
Indigenous American Ancestry*	1.00 (0.86, 1.16)	0.98 (0.84, 1.15)	0.95 (0.77, 1.17)	0.97 (0.78, 1.19)	0.93 (0.80, 1.08)	0.98 (0.83, 1.14)	0.96 (0.85, 1.08)	0.98 (0.87, 1.10)
Age at Diagnosis		0.99 (0.96, 1.00)		1.00 (0.98, 1.03)		1.02 (1.00, 1.04)		1.01 (1.00, 1.03)
AJCC Stage
Stage I–II		ref		ref		ref		ref
Stage III–IV		4.01 (2.3, 7.1)		7.35 (3.60, 15.0)		4.61 (2.65, 8.03)		3.65 (2.31, 5.76)
Hormonal Therapy
No		ref		ref		ref		ref
Yes		0.56 (0.32, 0.97)		0.49 (0.24, 1.00)		0.39 (0.23, 0.66)		0.57 (0.37, 0.88)

^*Per 10% increase in ancestry

^¥Adjusted for age at diagnosis (years), AJCC stage and hormonal therapy.