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Enzymatically-enhanced assay scheme with the signal response for the example system. The assay consists of (1) chip functionalization and protein blocking steps, (2) analyte capture from cell lysate, (3) binding of biotinylated tracer antibody, (4) binding of SA-HRP conjugate to biotinylated tracer, and (5) enzymatic signal enhancement via oxidation of 4CN to the insoluble product, 4-chloronaphthon. This figure was adapted from Wade et.al., ACS Cent. Sci. 2015, 1, 374–382.
