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. Author manuscript; available in PMC: 2018 Jan 24.
Published in final edited form as: Nat Chem Biol. 2017 Jul 24;13(9):1002–1008. doi: 10.1038/nchembio.2439

Figure 6. Inhibition of AP-DNA incision.

Figure 6

(a) Single- and multiple-turnover excision of YTMA by AlkD. All reactions contained 100 nM YTMA-DNA. The dashed line indicates the fraction product expected with 10 nM AlkD after one enzymatic turnover. (b) AP-DNA incision by ExoIII or EndoIV. (c,d) Incision of AP-DNA/YTMAde and THF-DNA/3mAde by 1 nM ExoIII (c) or EndoIV (d). Error bars in a, c, and d represent s.d. from three replicate experiments.