Table 1.

Summary of Amsterdam II and Revised Bethesda Criteria for the Evaluation of Lynch Syndrome.¹³

Amsterdam II (All criteria must be met)	Revised Bethesda
At least 3 relatives with a Lynch Syndrome associated cancer; one should be a first-degree relative of the other 2	Colorectal cancer diagnosed at age < 50
Familial adenomatous polyposis has been ruled out	Synchronous, metachronous or other Lynch Syndrome related tumors
Two affected generations	MSI-H colorectal cancer in a pt <60
At least one Lynch Syndrome associated cancer should be diagnosed < age 50	Colorectal cancer in ≥ 1 first-degree relatives with a Lynch Syndrome related tumor, one occurring at age <50
	Colorectal cancer in ≥ 2 first- or second-degree relatives with Lynch Syndrome related tumors