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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Semin Nucl Med. 2017 Jul 13;47(5):553–575. doi: 10.1053/j.semnuclmed.2017.06.003

Figure 12.

Figure 12

[18F]AV-1451 standardized uptake value ratio (SUVR) images in a tau-negative (tau-) cognitively normal elderly subject (top row) and a tau-positive (tau+) Alzheimer’s disease subject (bottom row) determined 80–100 min post injection. These are the same subjects shown in Fig. 8. Retention of [18F]AV-1451 in the cognitively normal subject shows elevated retention in basal ganglia (indicated by arrow) that is representative of off-target binding in elderly subjects. The AD subject also exhibits [18F]AV-1451 off-target binding in basal ganglia, but also high levels of radiotracer retention in the lateral temporal lobes.