Skip to main content
. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Semin Nucl Med. 2017 Jul 13;47(5):553–575. doi: 10.1053/j.semnuclmed.2017.06.003

Table 1.

Some Amyloid PET Radioligand Properties

  • Selectively binds amyloid

  • High affinity for amyloid (Kd ~1 nM)

  • Reversible binding to amyloid in vivo

  • Molecular weight <700 Da and logD = 1–3

  • Crosses the blood-brain barrier well

    • ≥0.4%ID/g in rat brain or ≥4.0% ID/g in mouse brain

    • ≃100 (%ID/g)*g body mass = 1 SUV unit (species independent)

  • Rapid brain clearance of compound not bound to target brain clearance t1/2 <30 min in rodents

  • No radiolabeled metabolites in brain