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Clearance of different 11C-labeled BTAs from mouse brain (ratio of 2 min brain concentration to 30 min brain concentration). The 6-OH-BTA-1 compound (PiB) demonstrated the highest clearance ratio of 11 indicating a clearance half-time of ~6 min.
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| Ratio of 2′-to-30′ mouse brain uptake | ||||
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| R4′ | ||||
| NH2 | NHCH3 | N(CH3)2 | ||
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| R6 | CH3 | - | 2.7 | 0.5 |
| H | - | 7.6 | 2.5 | |
| HO | - | 11 | 3.0 | |
| CH3O | 3.8 | 3.2 | 1.1 | |
