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APOL1 risk genotypes are known to associate with CKD, dramatically increasing the risk of renal dysfunction. Although kidney disease in general leads to increased rates of CVD outcomes, the contribution of APOL1 risk genotypes to the latter remains uncertain. Conflicting results have been reported with respect to the relationship between APOL1 risk genotypes and CVD, leaving the question open as to the association of APOL1 risk genotype and CVD.
