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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Am J Med Sci. 2017 May 30;354(3):310–318. doi: 10.1016/j.amjms.2017.05.018

FIGURE 5.

FIGURE 5

E-prostanoid receptor EP1 and EP4 may be responsible for prorenin-renin upregulation after subsequent stimulation of the (pro)renin receptor (PRR) mediating cyclooxygenase-2 (COX-2) upregulation during the late phase. M-1 cells were incubated with prostaglandin E2 (PGE2) 1 μmol and co-incubated with EP1 and EP4 antagonists at doses shown in the figure. As observed, both antagonists were able to prevent prorenin and renin upregulation. *P < 0.05 vs. vehicle (Veh), n = 6.