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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Trends Mol Med. 2017 Sep 5;23(10):917–931. doi: 10.1016/j.molmed.2017.08.002

Key Figure, Figure 1. Functional analysis of candidate arthritis causal variants in a human iPSC arthritis modeling platform.

Key Figure, Figure 1

Shown, is a schematic of arthritis modeling by editing candidate variants in human iPSCs and assaying the changes in induced cartilage tissue after administering disease-associated stimuli (i.e. inflammatory cytokines, mechanical loading). Candidate disease-modifying therapeutics might then be assayed to potentially reverse deficiencies in cells harboring genetic variants.