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Pictorial representation of elements in the normal bone marrow microenvironment. The bone marrow microenvironment (BM) contains multiple cell types such as osteoblasts, osteoclasts, endothelial cells, mesenchymal stromal cells, fibroblasts and adipocytes that can interact with normal hematopoietic stem cells (HSCs) and control hematopoiesis and quiescence. ECM proteins, specifically fibronectin and osteopontin, and soluble factors such as SDF-1 and galectins (green spheres).
