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Pictorial representation of the signaling pathway activated by VLA-5 binding to fibronectin. This interaction mediates the binding of scaffolding protein RACK1 to VLA-5 which recruits protein phosphatase PP2A. PP2A dephosphorylates GSK-3β on Ser 9 resulting in its activation. Activated GSK-3β signals via MAPK pathway to induce chemoresistance.
