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. Author manuscript; available in PMC: 2018 Jul 11.
Published in final edited form as: Semin Oncol. 2017 Jul 11;44(2):101–112. doi: 10.1053/j.seminoncol.2017.06.005

Table 10.

Physiological role of immunoglobulin superfamily (IgSF) proteins

Cell type/IgSF Consequences Reference
HSCs/CD47

  • CD47 binds to signal-regulatory protein-α on macrophages to prevent HSC phagocytosis

 (136)
Leukocyte CD47

  • CD47 also called integrin-associated protein (IAP) as it complexes with integrins and regulates leukocyte adhesion and migration to endothelial cells

 (137)
T-cell/CD28

  • T-cell activation

 (138)