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. Author manuscript; available in PMC: 2018 Jul 11.
Published in final edited form as: Semin Oncol. 2017 Jul 11;44(2):101–112. doi: 10.1053/j.seminoncol.2017.06.005

Table 11.

Role of immunoglobulin superfamily (IgSF) members in mediating chemoresistance in hematologic malignancies

Cell type/IgSF Consequences Reference/s
T-ALL/CD28

  • Functions as a T-cell co-stimulatory molecule with demonstrated role in T-cell proliferation, survival and differentiation

  • CD28 expression increased in Jurkat cells cultured in direct contact with stromal cells

  • CD28 is a target of Notch signaling known to play major role in microenvironment-induced drug resistance in TALL
Multiple myeloma/CD28

  • CD28 ligation to CD80/86 on bone marrow stromal cells activates PI3K/Akt signaling pathway leading to increased survival and protection from chemotherapy
CLL/CD47

  • CD47 promotes drug resistance in solid and hematological cancers
ALL, AML/CD47

  • CD47 is overexpressed in leukemia and is considered an indicator of poor prognosis

  • CD47 on AML cells allows AML cells to escape phagocytosis
B-ALL/CD147

  • CD147 is overexpressed in B-ALL samples collected at diagnosis from patients who suffered relapse

  • CD147 expression is further elevated in samples collected at relapse and also in B-ALL cells invading central nervous system

  • CD147 has numerous binding partners – CD147 itself, E-selectin, CD44, cyclophilins and integrins.

  • CD147 is also expressed on stromal cells
Lymphoma/CD147

  • CD147 plays an important role in drug resistance in other hematological malignancies such as murine lymphoma