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. Author manuscript; available in PMC: 2018 Jul 11.
Published in final edited form as: Semin Oncol. 2017 Jul 11;44(2):101–112. doi: 10.1053/j.seminoncol.2017.06.005

Table 13.

Role of ectoenzymes in mediating physiological functions and chemoresistance

Cell type/ectoenzyme Consequences Reference/s
B-ALL/CD10, neutral endopeptidase

  • CD10 is overexpressed in nearly half of B-ALL cases with sustained expression during relapse.

  • CD10 inhibits focal adhesion kinase and prevents the turnover of cell-matrix contacts

  • CD10 expression in ALL cells is positively correlated with the presence of an ion channel hERG1 (human ether-a-go-go related gene 1), which is associated with chemotherapy resistance
Head and neck squamous cell carcinoma/CD10

  • CD10 has also been identified as a marker for therapeutic resistance and as a cancer stem cell marker
CML/CD26, dipeptidyl peptidase 4

  • CD26 identified as a cancer stem cell marker in several cancer types including CML
Lymphoma/CD26

  • CD26 regulates adhesion by modulation of integrinβ1 phosphorylation via p38 MAPK
T-ALL/CD26

  • CD26 expression restricted to aggressive pathological entities such as T-ALL; however its role in ALL is not well studied
T-ALL/CD73, ecto-5′- nucleotidase

  • CD73 generates extracellular adenosine, interacts with death receptor, inhibits TRAIL-induced apoptosis and induces multi-drug resistance

  • CD73 is highly expressed in ALL and used for MRD monitoring
CLL/CD73

  • CD73 activity reduced drug-induced apoptosis