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. Author manuscript; available in PMC: 2018 Jul 11.
Published in final edited form as: Semin Oncol. 2017 Jul 11;44(2):101–112. doi: 10.1053/j.seminoncol.2017.06.005

Table 6.

Physiological role of cadherins involved in chemoresistance in hematological malignancies

Cell type/cadherin Consequences Reference/s
Endothelial cells/VE-cadherin (CD144)

  • VE-cadherin regulates endothelial junction permeability and leukocyte extravasation.
HSC/N-cadherin (CD325)

  • N-cadherin may be involved in HSC maintenance and adhesion to osteoblasts.
Epithelial cells/Fat1-cadherin

  • Fat1 cadherin, the largest cadherin in the cadherin family, regulates actin dynamics at cell-cell contacts and leading edge