Table 2.

Results table.

	Mercaptopurine (MP)	Azathioprine	Thioguanine (TG)
Result
Case 1: DMET test has not been ordered.
What message do we provide to the user?	Dose reductions are recommended in patients who have at least one dysfunctional TPMT-deficient allele. Testing for TPMT genotype is recommended.	Dose reductions are recommended in patients have at least one dysfunctional TPMT-deficient allele. Testing for TPMT genotype is recommended.	Dose reductions are recommended in patients who have at least one dysfunctional TPMT-deficient allele. Testing for TPMT genotype is recommended.
Do we allow medication to be ordered? (override reason required for “Yes”)	Yes	Yes	Yes
What are the override reasons?	Override reasons Patient has received medication in the past without reaction TPMT genotype from an outside lab has been determined and documented in CRIS Clinical justification documented in CRIS	Override reasons Patient has received medication in the past without reaction TPMT genotype from an outside lab has been determined and documented in CRIS Clinical justification documented in CRIS	Override reasons Patient has received medication in the past without reaction TPMT genotype from an outside lab has been determined and documented in CRIS Clinical justification documented in CRIS
Do we automatically pre-check the box for the DMET genotype test?	Yes – if not overridden	Yes – if not overridden	Yes – if not overridden
Case 2: DMET has been ordered but result has not been provided.
What message do we provide to the user?	A TPMT genotype test has been ordered but not yet resulted.	A TPMT genotype test has been ordered but not yet resulted.	A TPMT genotype test has been ordered but not yet resulted.
Do we allow medication to be ordered? (over-ride reason required for “Yes”)	Yes	Yes	Yes
What are the override reasons?	1. Clinical justification documented in CRIS	1. Clinical justification documented in CRIS	1. Clinical justification documented in CRIS
Case 3: DMET has been ordered and results are available	See message to prescriber in table below.	See message to prescriber in table below.	See message to prescriber in table below.