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. Author manuscript; available in PMC: 2018 Sep 21.
Published in final edited form as: Mol Cell. 2017 Aug 31;67(6):1013–1025.e9. doi: 10.1016/j.molcel.2017.07.028

Figure 5.

Figure 5

Effects of MYC levels on the transcriptome during the DNA DSB response. (A) Density plot of fold-changes in mean transcription in NCS-treated MYC-GFP cells (n = 3) relative to untreated GFP cells (n = 3) vs. fold-changes in mean transcription in NCS-treated GFP cells (n = 3) relative to untreated GFP cells (n = 3). Transcripts are divided into Groups I–IV based on their fold-change due to the DSB response and their fold-change due to MYC held above its basal level during the DSB response. (B–C) Examples of apoptosis- and cell cycle-related gene sets found to be significantly enriched in NCS-treated MYC-GFP cells over NCS-treated GFP cells. Normalized enrichment scores (NES), false discovery rate q-values, and nominal p-values are shown. See also Figure S3 and Table S2.