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. Author manuscript; available in PMC: 2018 Sep 21.
Published in final edited form as: Mol Cell. 2017 Aug 31;67(6):1013–1025.e9. doi: 10.1016/j.molcel.2017.07.028

Figure 7.

Figure 7

During the DSB response, p53 acts through MYC along with its other targets, suppressing transcription of most genes while selectively activating genes involved in the response. This redistribution of the transcriptome guides cell fate decisions.