. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: J Trace Elem Med Biol. 2017 Jun 6;44:40–49. doi: 10.1016/j.jtemb.2017.05.005

Table 2.

Properties and functions of Se proteins identified in QC03LH3 pygmy sperm whale liver.

Protein	Protein Class	Species	Sequence Length	MW (kDa)	Known function
Glutathione peroxidase 1	Selenoprotein	Bovine	205 AA	22.7	protects hemoglobin in red blood cells from oxidative breakdown
		Human	201 AA	21.9
		Common marmoset	201 AA	21.8
		Mouse	201 AA	22.3
		Pig	206 AA	22.6
		Rabbit	200 AA	21.9

Glutathione S-transferase A1	Se-binding	Bovine	222 AA	25.5	conjugation of reduced glutathione to hydrophobic electrophiles

Glutathione S-transferase P	Se-binding	Bovine	210 AA	23.6	conjugation of reduced glutathione to hydrophobic electrophiles; aids in detoxification with xenobiotic metabolism
		Long-tailed hamster	210 AA	23.6
		Pig	207 AA	23.5

Glyceraldehyde-3-phosphate dehydrogenase	Se-binding	Bovine	333 AA	35.9	involved in metabolic switch under oxidative stress allowing cells to produce more NADPH
		Human	335 AA	36.1
		Greater Egyptian jerboa	363 AA	39.4

Metallothionein-1A	Se-binding	Bovine	61 AA	6.0	high cysteine residue content binds heavy metals

Metallothionein-2	Se-binding	Human	61 AA	6.0	high cysteine residue content binds heavy metals

Metallothionein-3	Se-binding	Human	68 AA	6.9	binds heavy metals
Metallothionein-3	Se-binding	Wild yak	68 AA	6.9	binds heavy metals

Metallothionein-4	Se-binding	Dog	62 AA	6.2	binds heavy metals

Phospholipid hydroperoxide glutathione peroxidase	Selenoprotein	Human	197 AA	22.2	protects cells against membrane lipid peroxidation and oxidative damage

Selenium-binding protein 1	Se-binding	Bovine	472 AA	52.6	selenium-binding protein; involved in sensing reactive xenobiotics in the cytoplasm
Selenium-binding protein 1	Se-binding	Human	472 AA	52.4

Serum albumin	Se-containing	Bovine	607 AA	69.3	most abundant protein in plasma, regulates colloidal osmotic pressure of blood, acts as a plasma carrier by non-specific binding
Serum albumin	Se-containing	Human	609 AA	69.4

Thioredoxin reductase 1	Selenoprotein	Human	649 AA	70.9	reduces thioredoxin using NADPH

3-mercaptopyruvate sulfurtransferase	Se-binding	Human	297 AA	33.2	transfers sulfur-containing groups (Se can substitute) to thiol compounds; participates in cysteine metabolism