Table 4a.

Linear Regression: Associations Between Manufacturing Factors and “Postpurified” Quantity Parameters in Final Islet Product

Manufacturing Factors		IEQ (×1,000)	IEQ/g*	IEQ/IPN
		Coef.†	Coef.†	Coef.†
NAIDS	[> 80 vs. 65–80 (reference)]	121.3‡§		0.3¶
Cold ischemic time (h)	(≤10 vs. >10)	87.7§¶	893.2§¶
Enzyme brand	(liberase MTF vs. Serve-NB1 or Sigma V)	106.6‡	1,013.4¶
Collagenase#	(U/g of digested pancreas)		102.1‡§
Cannulation time (min)	(<30 vs. ≥30)	131.5‡§	1,643.3‡§	0.4‡§
Digestion time (min)	(≥10 vs. <10)			-0.3§¶
Dilution time (min)	(≥30 vs. <30)			0.3¶

Each cell description: regression coefficient in either multivariate (marked by §) or univariate linear regressions.

^*Total islet yield per gram of digested pancreas tissue;

^†coefficient from regression models;

^#collagenase defined as concentration of used collagenase per gram of digested pancreas tissue;

^§statistics calculated from multivariate regressions;

^‡p < 0.01;

^¶p < 0.05. NAIDS, North American Islet Donor Score; IEQ, islet equivalent; IPN, islet particle number.