Figure 1.

Cell phenotypes. (A) Frequency of T helper subpopulations (Th1∗/Th1/Th2/Th17) among the CD4⁺ tumor-infiltrating lymphocyte (TIL) subpopulation and C-X-C chemokine receptor type 3 (CXCR3) expression in the CD8⁺ or CD4⁻CD8⁻ TIL subpopulation from the parental CD3⁺ T-cell group. CD4⁺ TILs are Th1 polarized (CXCR3⁺CCR4⁻), and the majority of CD8⁺ or CD4⁻CD8⁻ TILs reside in the CXCR3 T-cell subsets. (B) Frequency of T-cell populations (CD45RA and CCR7) in parental CD3⁺ TILs. The majority of TILs reside in the CD45RA⁻CCR7⁺ (central memory) and CD45RA⁻CCR7⁻ (effector memory) T-cell subsets. Each dot represents the TIL line from a single individual.