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. 2017 Feb 1;26(2):259–269. doi: 10.3727/096368916X693527

Figure 1.

Figure 1.

Mean weight gain was utilized to assess overall health. Treatments included mutant sHW rats injected with hNPCs (n = 12) or dNPCs (n = 12) into the common carotid artery, mutant rats unilaterally implanted with hNPCs (n = 12) or dNPCs (n = 12) into the hippocampus and the cerebellum, and untreated mutant (n = 12) and normal rats (n = 12). The carotid injections of hNPCs elicited similar weight gain/loss compared to the dNPC group. Mutant sHW rats unilaterally implanted with hNPCs elicited significant weight gain compared to the dNPC group (p < 0.05). As expected, untreated normal rats showed the highest weight gain, while untreated mutant rats showed a decrease in weight due to the natural progression of their ataxia. All values are means ± SEM; asterisk indicates significant difference in weight between the live hNPC group and other mutants (p < 0.05). hNPCs, human-derived neural progenitor cells; dNPCs, dead neural progenitor cells; sHW, spastic Han–Wistar rats; SEM, standard error of the mean.