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. 2017 Sep 1;66(34):897–903. doi: 10.15585/mmwr.mm6634a2

TABLE. Average yearly changes in rates of overdose deaths involving heroin and synthetic opioids excluding methadone, and law enforcement drug reports of heroin and fentanyl, by census region — United States, 2006–2015.

Event, period National
U.S. Census region*
Northeast
Midwest
South
West
Rate change (95% CI) Rate change (95% CI) Rate change (95% CI) Rate change (95% CI) Rate change (95% CI)
Total deaths involving heroin
2006–2009
0.13 (0.01–0.26)
0.11 (-0.04–0.27)
0.26 (0.00–0.53)
0.08 (-0.10–0.26)
0.10 (0.02–0.18)
2010–2015
0.62 (0.55–0.68)†,§
1.02 (0.93–1.10)†,§
0.89 (0.74–1.03)†,§
0.49 (0.39–0.59)†,§
0.28 (0.24–0.33)†,§
Heroin drug reports
2006–2009
2.24 (0.51–3.96)
4.49 (-0.55–9.52)
4.88 (1.46–8.30)
0.24 (-0.77–1.26)
1.40 (-0.09–2.88)
2010–2015
4.52 (3.60–5.44)†,§
8.51 (5.81–11.20)
6.00 (4.17–7.83)
2.74 (2.20–3.28)†,§
3.33 (2.53–4.12)†,§
Total deaths involving synthetic opioids
2006–2012
0.01 (-0.05–0.06)
0.02 (-0.08–0.12)
-0.06 (-0.18–0.07)
0.03 (-0.02–0.08)
0.02 (-0.01–0.06)
2013–2015
0.98 (0.78–1.18)†,§
2.15 (1.77–2.52)†,§
1.35 (0.88–1.81)†,§
0.81 (0.63–0.98)†,§
0.07 (-0.07–0.20)
Fentanyl drug reports
2006–2012
-0.10 (-0.29–0.08)
-0.20 (-0.64–0.24)
-0.31 (-0.75–0.13)
-0.002 (-0.053–0.049)
0.017 (-0.002–0.037)
2013–2015
2.09 (1.40–2.79)†,§
5.08 (3.42–6.75)†,§
3.64 (1.99–5.29)†,§
1.08 (0.89–1.27)†,§
0.11 (0.03–0.18)†,§
Deaths involving heroin without synthetic opioids
2006–2012
0.17 (0.09–0.25)
0.26 (0.07–0.44)
0.33 (0.25–0.41)
0.08 (0.02–0.14)
0.10 (0.04–0.15)
2013–2015
0.33 (0.03–0.62)
0.31 (-0.37–0.99)
0.23 (-0.07–0.53)
0.43 (0.20–0.67)†,§
0.27 (0.05–0.49)
Deaths involving synthetic opioids without heroin
2006–2012
0.01 (-0.03–0.05)
0.02 (-0.05–0.08)
-0.05 (-0.14–0.04)
0.03 (-0.01–0.07)
0.02 (-0.01–0.06)
2013–2015
0.60 (0.45–0.75)†,§
1.31 (1.07–1.55)†,§
0.73 (0.38–1.07)†,§
0.54 (0.38–0.69)†,§
0.05 (-0.08–0.19)
Deaths involving use of both heroin and synthetic opioids
2006–2012
-0.001 (-0.021–0.020)
0.001 (-0.037–0.039)
-0.008 (-0.055–0.040)
0.002 (-0.010–0.013)
0.001 (-0.001–0.003)
2013–2015 0.384 (0.307–0.460)†,§ 0.842 (0.701–0.982)†,§ 0.622 (0.444–0.800)†,§ 0.269 (0.228–0.311)†,§ 0.014 (0.005–0.023)†,§

Abbreviation: CI = confidence interval.

* Northeast: Connecticut, Maine, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, and Vermont; Midwest: Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, and Wisconsin; South: Alabama, Arkansas, Delaware, District of Columbia, Florida, Georgia, Kentucky, Louisiana, Maryland, Mississippi, North Carolina, Oklahoma, South Carolina, Tennessee, Texas, Virginia, and West Virginia; West: Alaska, Arizona, California, Colorado, Hawaii, Idaho, Montana, Nevada, New Mexico, Oregon, Utah, Washington, and Wyoming.

Slope estimates are statistically significantly different from zero (p<0.05).

§ Slope for the later period is statistically significantly different from that of the earlier period (p<0.05).

Drug exhibits (i.e., drug products) obtained by law enforcement that tested positive for heroin or fentanyl and were reported to the Drug Enforcement Administration’s National Forensic Laboratory Information System.