Skip to main content
. 2017 Oct 26;12(10):e0186642. doi: 10.1371/journal.pone.0186642

Fig 4. Both domains of obscurin Ig58/Ig59 are involved in binding titin ZIg9/ZIg10.

Fig 4

HSQC chemical shift changes of Ig58/Ig59 upon the addition of 0.5x human titin ZIg9/ZIg10, mapped onto a model of obscurin Ig58/Ig59 (A) or by residue number (B). Gray denotes residues with no data; green denotes residues with no significant chemical shift changes; yellow denotes residues chemical shift changes greater than 2x standard deviation; red denotes residues experiencing a large drop in peak intensity of greater than 2.5x the average intensity. The two obscurin mutations linked to muscle disease, Arg4344 and Arg4444, are labeled and colored blue.