Table 2.
National practice guidelines for HBOC syndromes in selected countries in Latin America
| Country | National Guidelines | Genetic Counseling Criteria | Screening and management recommendations | Healthcare public insurance coverage |
|---|---|---|---|---|
| Argentina(51) | Guidelines for the detection and study of high-risk hereditary breast cancer cases. National Intersociety Consensus for high risk of breast cancer. 2014 |
BC < 50 y; bilateral/multicentric BC; BC in male; BC in AJ; ≥ 2 first/second degree relative; BC + other primary or; TNBC < 60 y. Families with BC + OC; BC + endometrial or thyroid cancer; BC + pediatric cancer or; BC + GI cancer. |
Annual breast MRI and mammogram RRM RRSO after child bearing completion (BRCA mutation) Chemoprevention if RRM not performed. |
No |
| Brazil(50) | Operational Manual. National Hereditary Cancer Network. 2009 | BC ≥ 3 cases + OC case; BC > 3 cases ≤ 50 y or; 2 sisters or mother and daughter < 50 y with one of the followings: 2 BC cases; or 2 OV cases; or BC + OC | Monthly breast self exam Annual or every 6 mo clinical breast exam Annual mammogram Breast MRI (6 mo after the mammogram) Transvaginal ultrasound + Ca 125 (every 6 mo) |
No |
| Colombia(48) | Guideline for the early detection, treatment, follow-up and rehabilitation of breast cancer. (2013) | BC < 30 y; BC in 2 FDR <40 y; or 3 FDR <50 y; or 4 FDR < 60 y; or 6 relatives (any age); BR + FDR < 50 y; OC + BR in FDR < 50 y; OC in 2 FDR; bilateral OC recurrent OC after 2 y of initial diagnosis; OC < 40 y; BC or OC in AJ Ancestry; male BC or; BC or OC < 50 y + other BRCA related cancer (BC, OC, endometrium, colon, small bowel, gastric, biliary, pancreatic, prostate, melanoma or sarcoma). | Annual Breast MRI or Mammogram + US (if MRI is not available or contraindicated) RRM RRSO Chemoprevention |
No |
| Mexico(49) | Mexican Official Norm (NOM-041-SSA2-2011) for breast cancer prevention, diagnosis, treatment and surveillance. | Personal history of BC < 40 y; bilateral BC, BC + OC; Family history of BC in ≥ 2 FDR; BC in male; relative with BC + OV; > 1 generations with cancer (colon, pancreas, prostatic); > 1 OC; AJ ancestry; high risk gene mutation; |
Breast self examination; Clinical breast exam every 6 mo; Annual breast image (mammogram, ultrasound or MRI according to age and resources; Annual social and psychological support Chemoprevention; RRSO RRMO |
No |
*
AJ= Ashkenazi Jewish; BC= breast cancer; FDR= first degree relative; GI= gastrointestinal; HBOC= hereditary breast and ovarian cancer; mo= months; MRI= magnetic resonance imaging; OC = ovarian cancer; RRMO= risk reduction mastectomy; RRSO= risk reduction salpingoophorectomy; TNBC= triple negative breast cancer; y= year