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. Author manuscript; available in PMC: 2018 Sep 21.
Published in final edited form as: Cell. 2017 Sep 7;171(1):217–228.e13. doi: 10.1016/j.cell.2017.08.006

Figure 5. CIP is a distinct chronic itch disorder that exhibits severe itch despite minimal skin inflammation.

Figure 5

(A–B) Representative clinical pictures of (A) atopic dermatitis (AD) and (B) chronic idiopathic pruritus (CIP).

(C–D) Representative H&E histopathology of pruritic sites from (C) AD and (D) CIP.

(E) Histology score of AD and CIP patient biopsies, N ≥ 4 biopsies per group.

(F) Numerical Rating Scale (NRS) itch scores of AD and CIP patients, N ≥ 22 patients per group.

(G) Clustering of AD, CIP, and control skin samples by row Z-scores of the regularized logarithm of gene expression values of the top 100 differentially expressed genes from RNA-seq of AD versus control skin, N = 4 donors per condition.

Scale bars indicate 100 μm. Data are represented as mean ± SEM. See also Tables S1–S3.