Figure 1. The future state-of-the-art myofilament field.

For the field to progress in an effective and rigorous manner, multimodal approaches to studying myofilament structure, function and regulation should be given increasing attention. Basic biology should be used along with advanced technologies to provide new pathways for translational research to understand and treat human cardiac diseases. The overall goal should be to generate consistent and reproducible unbiased observations that can build the foundation for these basic, clinical and translational studies in a collaborative manner.