Fig 4. Adjuvanted DS-Cav1 can augment RSV-neutralization titers in elderly mice.

(A) Pre-immunized elderly mice (DS-Cav1 adjuvanted with Poly (I:C), ~85 weeks wait) were administered DS-Cav1 formulated with Alum or SAS + Carbopol and the immune response for all mice assessed. (B) Neutralization titers for each group of seven elderly mice are shown. Scatter plots show the geometric mean (numerical value below), the palivizumab protective threshold is indicated by a dotted line [10]. p values were determined by two-tailed Wilcoxon matched-pairs signed rank test, p = >0.05 (ns); p < 0.05 (*). Associated raw data is reported in S4 Table.