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. 2017 Oct 26;12(10):e0186854. doi: 10.1371/journal.pone.0186854

Fig 6. Prime-boost vaccination with different adjuvant formulations induced a balanced Th1/Th2 IgG response in elderly mice.

Fig 6

(A) Pre-immunized elderly mice (~85 weeks wait) were administered DS-Cav1 formulated with SAS + Carbopol or Alum. Sera were assayed by ELISA for their DS-Cav1 specific IgG1 and IgG2a antibody responses. Closed circles and open triangles represent IgG1 and IgG2a antibody titers, respectively. (B) The ratios of IgG1 to IgG2a for each animal in the groups were calculated from the upper panel. p values were determined by two-tailed Wilcoxon matched-pairs signed rank test, p = >0.05 (ns). Associated raw data is listed in S6 Table.