| Aluminium salts (Aluminium hydroxide) |
Gel suspension |
Inflammasome activation; Th2 biased response [29],[30] |
| Poly (I:C) |
dsRNA (Inosine, cytidine homologue) |
TLR3 Agonist (immunomodulatory molecule) [31] |
| Poly (IC:LC) |
dsRNA (Complex of carboxymethylcellulose, polyinosinic-polycytidylic, and poly-L-lysine double-stranded RNA) |
TLR3 Agonist (immunomodulatory molecule) [24] |
| Monophosphoryl Lipid A-SM |
Phospholipid |
Surface PRR activation; TLR4 agonist, Immunomodulatory molecule [32] [33, 34]. |
| Sigma Adjuvant System (SAS) |
Oil-in-water emulsion, MPLA and trehalose dicorynomycolate |
Enhanced antigen uptake; TLR4 agonist |
| MPLA + Alum |
Phospholipid plus gel suspension |
TLR4 agonist, combination |
| SAS + Carbopol |
Oil-in-water emulsion, MPLA, trehalose dicorynomycolate. Polyanionic high mol. weight acrylic acid |
TLR4 agonist and controlled release of antigen[21] |
| Adjuplex |
Lecithin & Carbomer (cross-linked polyacrylic acid) homopolymer |
Th1/Th2 balanced response [19] |
| AddaVax |
Squalene based Oil in Water Emulsion |
Th1/Th2 balanced response[35] |
| MontanideTM ISA 71 VG |
Water in oil emulsion |
Th1/Th2 balanced response |
| MontanideTM ISA 71 VG + Carbopol |
Water in oil emulsion. Polyanionic high mol. weight acrylic acid |
Th1/Th2 balanced response and controlled release of antigen |
