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. 2017 Oct 26;12(10):e0186856. doi: 10.1371/journal.pone.0186856

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© 2017 Sethi et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 11 — Trial Sequential Analysis (TSA) showed that there was not enough information to confirm or reject a mean difference of 4.20% (TSA-adjusted confidence interval -2.37 to 10.77). The Z-curve (the blue line) does not cross any boundaries.