Table 2. Leukocyte subset numbers.
| Lean controls | Obese-pre | Obese-post | |
|---|---|---|---|
| Innate immunity | |||
| Monocytes (total) | 400 (300–600) * | 300 (300–400) * | 400 (300–500) |
| CD14++CD16- | 352 (255–542) | 244 (196–303) | 330 (245–374) |
| CD14++CD16+ | 15 (11–19)* | 16 (13–22)* | 18 (13–39) |
| CD14+CD16++ | 37 (33–94) | 39 (30–79) | 40 (36–69) |
| Natural Killer cells (CD16+CD56+) | 150 (80–211) | 224 (116–321) | 226 (134–287) |
| CD16+CD56++ | 8.7 (5.5–12) | 8.0 (4.9–13) | 9.3 (5.8–12) |
| CD16-CD56++ | 4.9 (2.8–8.0) | 5.5 (3.4–8.1) | 5.0 (4.4–8.9) |
| Bridging immunity | |||
| Natural Killer T cells | 1.2 (0.6–2.2) | 1.4 (0.9–3.9) | 1.2 (1.0–3.6) |
| Adaptive immunity | |||
| B cells | |||
| Naive (CD10-CD27-) | 178 (132–270) *# | 255 (189–454) * | 316 (224–454) # |
| Memory (CD10-CD27+) | 48 (41–73) | 69 (45–113) | 74 (56–117) |
| Immature transition (CD10+CD27+) | 10 (5.4–17) * | 23 (9.3–39) * | 15 (10–31) |
| CD4+ T helper cells | |||
| CD45RO- CXCR3- | 511 (451–700) | 639 (401–750) | 624 (334–937) |
| CD45RO- CXCR3+ | 58 (40–176) | 58 (32–110) $ | 85 (68–162) $ |
| CD45RO+ CXCR3- | 140 (115–196) | 151 (125–227) | 207 (103–251) |
| CD45RO+ CXCR3+ | 111 (84–134) | 67 (43–115) | 84 (57–117) |
| CD8+ cytotoxic T cells | |||
| CD45RO- CCR7- | 76 (37–138) | 76 (43–178) | 94 (29–161) |
| CD45RO- CCR7+ | 284 (275–358) | 355 (272–434) | 294 (238–477) |
| CD45RO+ CCR7- | 82 (44–85) | 56 (38–91) | 52 (42–73) |
| CD45RO+ CCR7+ | 15 (12–19) | 13 (8.6–30) | 18 (13–22) |
| Regulatory T cells (CD25+CD127-) | 26 (14–35) | 21 (16–28) | 22 (13–33) |
Leukocyte subset numbers (x 106) of lean controls compared to obese children pre-lifestyle intervention (pre) and post-lifestyle intervention (post). Data are presented as median (interquartile range).
* p<0.05 for lean controls compared to obese-pre.
# p<0.05 for lean controls versus obese-post.
$ p<0.05 for obese-pre compared to obese-post.