Table 5. Leptin receptor expression.
| Lean controls | Obese-pre | Obese-post | |
|---|---|---|---|
| Innate immunity | |||
| Monocytes (total) | 96 (95–98) | 97 (92–98) | 97 (94–98) |
| CD14++CD16- | 99 (99–100) | 100 (99–100) | 100 (99–100) |
| CD14++CD16+ | 100 (99–100) | 100 (99–100) | 100 (99–100) |
| CD14+CD16++ | 70 (61–81) | 75 (65–84) | 77 (77–81) |
| Natural Killer cells (CD16+CD56+) | 8.0 (5.3–12) | 8.8 (3.3–18) | 6.1 (4.4–10) |
| CD16+CD56++ | 7.2 (5.3–9.6) | 5.7 (3.0–14) | 6.2 (3.0–9.7) |
| CD16-CD56++ | 6.6 (5.9–7.7) | 5.3 (3.1–7.1) | 6.4 (2.9–7.8) |
| Bridging immunity | |||
| Natural Killer T cells | 11 (5.8–19) | 13 (5.2–32) | 9.8 (8.7–18) |
| Adaptive immunity | |||
| B cells | |||
| Naive (CD10-CD27-) | 51 (44–56) | 51 (46–58) | 47 (46–55) |
| Memory (CD10-CD27+) | 60 (57–65) | 63 (54–65) | 57 (50–62) |
| Immature transition (CD10+CD27+) | 46 (39–54) | 50 (35–57) | 46 (39–51) |
| CD4+ T helper cells | |||
| CD45RO- CXCR3- | 31 (28–40) | 29 (24–41) | 28 (24–36) |
| CD45RO- CXCR3+ | 69 (59–93) | 62 (50–73) | 71 (64–80) |
| CD45RO+ CXCR3- | 26 (22–29) | 25 (21–26) | 24 (21–29) |
| CD45RO+ CXCR3+ | 42 (29–50) | 41 (28–49) $ | 55 (44–66) $ |
| CD8+ cytotoxic T cells | |||
| CD45RO- CCR7- | 22 (16–26) | 22 (17–34) | 25 (19–29) |
| CD45RO- CCR7+ | 41 (31–52) | 39 (31–52) | 38 (32–48) |
| CD45RO+ CCR7- | 21 (19–32) | 24 (19–32) | 28 (24–31) |
| CD45RO+ CCR7+ | 65 (56–72) | 67 (48–87) | 69 (61–80) |
| Regulatory T cells (CD25+CD127-) | 10 (7.8–17) | 12 (5.9–15) | 13 (11–17) |
Percentage expression of leptin receptor on leukocyte subsets of lean controls compared to obese children pre-lifestyle intervention (pre) and post-lifestyle intervention (post). Data are presented as median (interquartile range).
$ p<0.05 for obese-pre compared to obese-post.