Table 2. Ubiquinated peptides with differential abundance in the Cyp46a1-/- brain as compared to the wild type brain.
| Protein | Peptide Sequence | Ubiquitination Site | Ratio (KO/WT) |
Biological Process |
|---|---|---|---|---|
| STX1B | LAIFTDDIKMDSQMoTK | K9 | KO only | Cognition |
| ATP1A2 | IMoDSFKNMoVPQQALVIR | K6 | KO only | Cognition, energy production |
| ALDOA | IVAPGKGILAADESTGSIAK | K6 | KO only | Energy production |
| TUBA1A | VGINYQPPTVVPGGDLAKVQR | K18 | KO only | Cytoskeleton function |
| YWHAZ | NLLSVAYKNVVGAR | K8 | 50.1 | |
| UBE2N | ICLDILKDK | K7 | 1.8 | Ubiquitination |
KO, Cyp46a1-/- brain; WT, wild type brain, Mo, oxidized methionine.