Table 3. Phosphoproteins with different phosphopeptide abundance in the Cyp46a1-/- brain as compared to the wild type brain.
| Abnormal Spatial Learning | Abnormal Motor Learning | Impaired Ability to Fire Action Potentials | Abnormal Neurotransmitter Secretion | Abnormal Synaptic Vesicle Clustering |
|---|---|---|---|---|
| ADD2 (↓) | HCN1 (↓) | KCNA2 (↓) | STXBP1 (↓) | CTNNB1 () |
| AMPH (↓) | MAPT (↓) | KCNMA1 (↓) | SYN1 (↓) | KIF1A (↓) |
| ATP1A2 () | SHANK3 (↓) | MADD () | SYT1 () | SYN1 (↓) |
| CTNND2 (↓) | SLC24A2 (↓) | Increased Synaptic Depression | Abnormal Synaptic Vesicle Number | Abnormal Synaptic Transmission |
| HCN1 (↓) | Reduced Long Term Potentiation | KCNMA1 (↓) | BSN (↓) | BSN (↓) |
| MAPT (↓) | ADD2 (↓) | SYN1 (↓) | DNAJC6 (↓) | SHANK3 (↓) |
| NCAM1 (↓) | CCDC88A (↓) | SYT1 () | KIF1A (↓) | STXBP1 (↓) |
| PRKCG (↓) | CTNNB1 () | Abnormal Neuron Physiology | MADD () | SYT1 () |
| SHANK2 (↓) | MAPT (↓) | HCN2 (↓) | MAP6 (↓) | Abnormal Nervous System Electrophysiology |
| SHANK3 (↓) | PRKCG (↓) | KCNQ2 (↓) | PCDH17 (↓) | ATP1A2 () |
| SLC24A2 (↓) | SHANK2 (↓) | SHANK3 (↓) | Abnormal Synaptic Vesicle Recycling | HCN1 (↓) |
| SLC8A2 (↓) | SHANK3 (↓) | SLC8A2 (↓) | AMPH (↓) | HCN2 (↓) |
| Abnormal Long Term Object Recognition Memory | SLC24A2 (↓) | SYT1 () | DNAJC6 (↓) | KCNA2 (↓) |
| BRAF (↓) | Abnormal Long Term Depression | Abnormal Axon Morphology | SYN1 (↓) | PLCL1 (↓) |
| CCDC88A (↓) | SHANK3 (↓) | ANK2 (↓) | Abnormal Excitatory Postsynaptic Currents | Axon Degeneration |
| MAPT (↓) | SLC24A2 (↓) | DST (↓) | CCDC88A (↓) | DST (↓) |
| SHANK3 (↓) | SLC8A2 (↓) | MADD () | KIF1A (↓) | |
| Abnormal Contextual Conditioning Behavior | Abnormal Cerebellum Morphology | GAP43 (↓) | PRKCG (↓) | NEFH () |
| ADD2 (↓) | MAP1B (↓) | SHANK3 (↓) | STXBP1 (↓) | |
| AMPH (↓) | ATP2B2 (↓) | MAPT (↓) | SLC1A3 (↓) | |
| CTNND2 (↓) | CIT (↓) | NEFH () | SYT1 () | |
| MAP2 (↓) | MAP1B (←↓) | PLEC (↓) | ||
| MAPT (↓) | MYO5A (↓) | |||
| PRKCG (↓) | NCAM1 (↓) |
Phosphoproteins were grouped by the GeneAnalytics (LifeMap Sciences) software and are shown based on involvement in brain processes pertinent to cognition.
↑ or ↓ indicate an increase or decrease, respectively, in the phosphopeptide abundance.
Proteins in bold are those with 2 or more phosphopeptides with differential abundance in the Cyp46a1-/- brain as compared to the wild type brain.