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. 2017 Oct 16;13(10):e1007038. doi: 10.1371/journal.pgen.1007038

Fig 1. hpk-1 activity is necessary and sufficient to regulate lifespan.

Fig 1

(A) hpk-1(pk1393) null mutant animals (red) are short-lived relative to wild-type N2 (black). Phpk-1::hpk-1::GFP largely restores wild-type lifespan to hpk-1(pk1393) mutant animals (green). Lifespan of non-transgenic hpk-1(pk1393) siblings (blue) is similar to hpk-1(pk1393). (B) Overexpression of hpk-1 using the heterologous sur-5 promoter increases lifespan compared to N2 (dark red versus black). Each graph is representative of at least 3 independent lifespan experiments. Full lifespan data can be found in S1 Table.