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. 2017 Oct 16;13(10):e1007038. doi: 10.1371/journal.pgen.1007038

Fig 12. HPK-1 is essential for the transcriptional activation of autophagy.

Fig 12

(A) hpk-1 is necessary for the induction the autophagy genes atg-18 and bec-1 (Beclin1) in response to inactivation of TORC1 by daf-15(RNAi) (** indicates p<0.01, Student’s t-test). (B) In contrast, decreased TORC1 signaling represses the expression of the translation initiation factor genes ifg-1 and iftb-1 independently from hpk-1. (C) Similarly, TORC1 inhibition mildly induces hsp-16.2 and hsp-70 independently from hpk-1. Columns labeled hpk-1 indicate hpk-1(pk1393). Expression levels are presented as fold change +/- S.D. normalized to cdc-42 and averaged across four independent experiments.