Skip to main content
. 2017 Oct 16;13(10):e1007038. doi: 10.1371/journal.pgen.1007038

Fig 13. pha-4 and mxl-2 are required for hpk-1 to promote longevity.

Fig 13

(A) Overexpression of hpk-1 increases lifespan (grey versus black) and is pha-4 dependent (red traces). (B) Overexpression of hpk-1 increases lifespan dependent on mxl-2 (blue traces). (C) Loss of hlh-30 (green traces) partially suppresses the increased lifespan of hpk-1, consistent with parallel signaling or independence. (D) Loss of nhr-62 (pink/purple traces) has a minimal negative effect on both normal and the increased lifespan conferred by hpk-1 overexpression. In all cases, black traces are N2 and grey traces are Psur-5::HPK-1::CFP animals treated on control RNAi. For each panel, darker colored traces are respective RNAi-treatment of N2 animals and lighter colored traces are RNAi treatment of Psur-5::HPK-1::CFP animals. In some cases, experiments shown within this figure were performed simultaneously and split into multiple figures for readability. Full lifespan data can be found in S1 Table.